Enum: ComponentInteractionTypeEnum

What the subject of a SampleComponentInteraction does to its object. Each term reads in the direction subject to object. Some relationships are symmetric - base_pairs_with, crosslinked_to, forms_complex_with, competes_with, no_interaction - and the row is still ordered: write one row, not two, and put the target or the larger partner as the object where there is a choice.

URI: lambda:ComponentInteractionTypeEnum

Permissible Values

Value	Meaning	Description
binds	None	Subject binds object non-covalently, where a more specific term does not appl...
inhibits	None	Subject inhibits object
activates	None	Subject activates object
is_substrate_of	None	Subject is a substrate of object, an enzyme
is_product_of	None	Subject is a product of object, an enzyme
is_cofactor_of	None	Subject is a cofactor, coenzyme or prosthetic group of object
is_coordinated_by	None	Subject, a metal ion, is coordinated by object
cleaves	None	Subject cleaves object, as a nuclease cleaves its target strand or a protease...
covalently_modifies	None	Subject adds a covalent modification to object, as a kinase phosphorylates it...
covalently_linked_to	None	Subject is covalently bonded to object: a covalent inhibitor, a glycan, a lip...
crosslinked_to	None	Subject is joined to object by a chemical crosslinker
base_pairs_with	None	Subject, a nucleic acid, is base-paired with object: the two strands of a dup...
embedded_in	None	Subject, a membrane protein, sits in object, a membrane mimetic
solubilized_by	None	Subject is kept in solution by object, a detergent or amphipol
encapsulated_in	None	Subject is enclosed by object: a genome in a capsid, a cargo in a liposome
forms_complex_with	None	Subject and object are parts of one assembly, where the nature of the contact...
competes_with	None	Subject competes with object for the same site on a third component
no_interaction	None	Subject is expected not to interact with object: a negative control pairing

Slots

Name	Description
interaction_type	What the subject does to the object

Identifier and Mapping Information

Schema Source

• from schema: http://w3id.org/lambda/

LinkML Source

name: ComponentInteractionTypeEnum
description: 'What the subject of a SampleComponentInteraction does to its object.
  Each term reads in the direction subject to object. Some relationships are symmetric
  - base_pairs_with, crosslinked_to, forms_complex_with, competes_with, no_interaction
  - and the row is still ordered: write one row, not two, and put the target or the
  larger partner as the object where there is a choice.'
from_schema: http://w3id.org/lambda/
rank: 1000
permissible_values:
  binds:
    text: binds
    description: Subject binds object non-covalently, where a more specific term does
      not apply
  inhibits:
    text: inhibits
    description: Subject inhibits object
  activates:
    text: activates
    description: Subject activates object
  is_substrate_of:
    text: is_substrate_of
    description: Subject is a substrate of object, an enzyme
  is_product_of:
    text: is_product_of
    description: Subject is a product of object, an enzyme
  is_cofactor_of:
    text: is_cofactor_of
    description: Subject is a cofactor, coenzyme or prosthetic group of object
  is_coordinated_by:
    text: is_coordinated_by
    description: Subject, a metal ion, is coordinated by object
  cleaves:
    text: cleaves
    description: Subject cleaves object, as a nuclease cleaves its target strand or
      a protease its substrate
  covalently_modifies:
    text: covalently_modifies
    description: Subject adds a covalent modification to object, as a kinase phosphorylates
      its substrate
  covalently_linked_to:
    text: covalently_linked_to
    description: 'Subject is covalently bonded to object: a covalent inhibitor, a
      glycan, a lipid anchor'
  crosslinked_to:
    text: crosslinked_to
    description: Subject is joined to object by a chemical crosslinker
  base_pairs_with:
    text: base_pairs_with
    description: 'Subject, a nucleic acid, is base-paired with object: the two strands
      of a duplex, a guide with its target'
  embedded_in:
    text: embedded_in
    description: Subject, a membrane protein, sits in object, a membrane mimetic
  solubilized_by:
    text: solubilized_by
    description: Subject is kept in solution by object, a detergent or amphipol
  encapsulated_in:
    text: encapsulated_in
    description: 'Subject is enclosed by object: a genome in a capsid, a cargo in
      a liposome'
  forms_complex_with:
    text: forms_complex_with
    description: Subject and object are parts of one assembly, where the nature of
      the contact is not specified. Symmetric; one row, target as object
  competes_with:
    text: competes_with
    description: Subject competes with object for the same site on a third component
  no_interaction:
    text: no_interaction
    description: 'Subject is expected not to interact with object: a negative control
      pairing'